Clinical Trials to Treat Brain Health Disorders in Persons with HIV

Scott Letendre

Scott Letendre, M.D., is Professor in Residence in the Division of Infectious Diseases and Global Public Health and the Department of Psychiatry at the University of California, San Diego (UCSD). Dr. Letendre performs translational, patient-oriented research of the central nervous system complications of chronic infections like HIV and CMV. This includes observational cohort studies and interventional clinical trials that focus on the neurological, cognitive, and mood effects of comorbidities and polypharmacy, the pharmacokinetics of antiretroviral drugs, and the biomarker correlates of disease. He has chaired the Neurology Collaborative Science Group of the AIDS Clinical Trials Group, the International Workshop on HIV & Aging, and the UCSD Institutional Biosafety Committee. He leads the NIH-funded, multicenter CHARTER Plus cohort (Cns Hiv AntiRetroviral Therapy Effects Research) in the U.S. and has participated in international research projects in China, India, Romania, Russia, Zambia, and Mozambique. Dr. Letendre has mentored more than 75 trainees; has received a K24 mentoring award from the National Institute of Mental Health; and leads two NIH-funded training programs. Dr. Letendre balances his research activities with outpatient and inpatient clinical care of persons with HIV and other infectious diseases. He also teaches in the Microbiology course at the UCSD School of Medicine as well as a graduate course on research methods. Dr. Letendre has co-authored over 350 peer-reviewed manuscripts published in journals such as AIDS, Antimicrobial Agents and Chemotherapy, Brain, Clinical Infectious Diseases, Journal of Antimicrobial Chemotherapy, Journal of Infectious Diseases, Journal of Neurovirology, Journal of Virology, Lancet HIV, and Neurology.

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Leveraging mRNA and lipid nanoparticle technology to develop a cure for HIV

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HIV and the Nervous System: Biotypes and viral persistence